Intercourse variations in reactions to pain that is experimental been examined making use of a wide variety of stimulus modalities including technical (dull stress and punctate technical stimuli), electrical, thermal (heat and cool), ischaemic, and chemical stimuli ( ag e.g. capsaicin, hypertonic saline). Increasingly in the last few years, more advanced experimental discomfort models have already been utilized to characterize dynamic problem modulatory processes, such as for instance temporal summation of discomfort (discomfort facilitatory measure) and trained pain modulation (measure of discomfort inhibition). Soreness responses have already been evaluated by several different result measures including behavioural indices of limit (defined by time or strength towards the sensation that is first of) and threshold, and self-report measures of discomfort strength and unpleasantness. Past qualitative and quantitative reviews have generally speaking figured ladies show greater sensitiveness to numerous pain modalities weighed against males, and that females show greater temporal summation of discomfort while guys display greater trained pain modulation. 1,4,8,23,24 in comparison, a recently available systematic review determined that ‘10 several years of laboratory research haven’t been effective in creating an obvious and constant pattern of intercourse differences in individual discomfort sensitivity’. 5 A quantitative analysis of this studies that served once the foundation of their summary did but expose a really constant pattern of leads to the way of greater discomfort sensitivity in females. 4 Figure 1 offers a graphical presentation of a dataset that reflects the normal pattern of findings across studies of sex variations in experimental discomfort reactions, that will help give an explanation for varying interpretations by some writers (for details regarding methodology see refs 25,26 ).